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Schematic illustration of drug loading, cellular entry, drug release, and antitumor mechanism of LHD/miR-375.
Abbreviations: DOX, doxorubicin hydrochloride; HMSN, hollow mesoporous silica nanoparticles; LHD, lipid-coated hollow mesoporous silica nanoparticles containing doxorubicin hydrochloride; MDR, multidrug resistance; MMP, mitochondrial membrane potential; PEG, polyethylene glycol; P-gp, P-glycoprotein.
