Figure 6.

DOX distribution followed administration of DOX or LHD in xenograft tumor mice.

Notes: (A) Tissue distribution and blood concentration of DOX at 0.5, 1, 2, 4, 8, 12, and 24 h after a single intravenous injection of DOX (8 mg/kg) or LHD (8 mg/kg DOX) in mice. DOX concentrations were determined using a fluorescence spectrometer and calculated using a standard curve. (B) Images of LHD distribution in mouse tissues. Data are expressed as mean ± standard error of the mean of three samples.

Abbreviations: DOX, doxorubicin hydrochloride; LHD, lipid-coated hollow mesoporous silica nanoparticles containing doxorubicin hydrochloride.