Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2017 Jul 24;12:5271–5287. doi: 10.2147/IJN.S135306

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2017 Xue et al. This work is published and licensed by Dove Medical Press Limited

The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.

PMC Copyright notice

Antitumor effects of LHD/miR-375 in Akt/Ras-induced HCC mice.

Notes: (A) Overall diagram of study design. (B) Liver morphology and Ki67 analysis of mice treated with saline, free DOX, LH/miR-375, LHD, or LHD/miR-375 (equivalent of 6 mg/kg DOX or 4 nmol/kg miR-375) for 2 weeks. (C) The average liver weights for each group (n=3). (D) Body weight changes (n=3) during experimental period since the Akt/Ras injections. The arrow refers to the first time of drug administration. (E) Hematoxylin and eosin staining of HCC mouse organs after treatment with drugs. Mouse organs or tumor tissues were collected after killing the mice at the end of experiment. Magnification: 200×. *P<0.05; ***P<0.001.

Abbreviations: DOX, doxorubicin hydrochloride; HCC, hepatocellular carcinoma; LH, lipid-coated hollow mesoporous silica nanoparticles; LHD, lipid-coated hollow mesoporous silica nanoparticles containing doxorubicin hydrochloride.