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. Author manuscript; available in PMC: 2018 Jul 10.
Published in final edited form as: Curr Biol. 2017 Jun 29;27(13):1941–1955.e6. doi: 10.1016/j.cub.2017.06.004

Figure 6. Muscle-derived Upd2 Mediates Muscle-dependent Effects on Systemic Lipid Homeostasis.

Figure 6

(A–D) Changes in systemic lipid metabolism upon mu-specific depletion of Foxo and Upd2

(A) Total TAG levels of whole flies. n=5 samples.

(B,D) ORO stain of dissected carcass/fat body and intestines. Intensity quantification of ORO, n=8–15 samples.

(C) Nile red stain (for LD) of dissected carcass/fat body; nile red (red) and DAPI (blue) detected by immunostaining.

(E) Proposed model depicting the communication axes between the muscle, CC/AKH producing cells, and fat storages tissues.

Bars represent mean±SE. All controls animals represent Act88FGal4>+(w1118).

See also Figures S5 and S6.