Figure 9. The Dynamic mode enables a faster targeting route for FtsY molecules not pre-activated at the membrane.

(A, B) Depiction of the two thermodynamically equivalent routes to attain the targeting complex bound at membrane in the Stable mode. (C) Rate constants for the early-to-closed rearrangement in the cytosol ($k_{switch}^{cyto}$) and on the membrane ($k_{switch}^{mem}$). Values were reported as mean ± S.D. with n = 3. (D) Simulation of the kinetics of RNC targeting to membrane via the routes depicted in parts A (magenta) and B (blue).

DOI: http://dx.doi.org/10.7554/eLife.25885.023