Table 4.

Association between MRI abnormalities and grade of Neonatal Encephalopathy

	Mild NE (n=48)	Moderate NE (n=35)	Severe NE (n=6)	p value
Normal	22 (46)	16 (46)	3 (50)	0.98
Isolated IVH	4 (8)	1 (3)	0	0.46
Isolated Cerebellar Hemorrhage	2 (4)	2 (6)	0	0.81
Isolated Sinus Venous Thrombosis	0	1 (3)	0
Punctate white matter lesion	2 (4)	2 (6)	0	0.81
Injury Consistent with Barkovich Classification	18 (38)	13 (37)	3 (50)	0.83
Basal Ganglia/Thalamic Injury	2 (4)	3 (9)	2 (34)	0.032
Severity of Basal Ganglia/Thalamic Injury†
1. Abnormal signal in the thalamus	2 (4)
2. Abnormal signal in the thalamus and lentiform nucleus		1 (3)	1 (17)
3. Abnormal signal in the thalamus, lentiform nucleus, and perirolandic cortex		2 (6)	1 (17)
4. More extensive involvement
Watershed Injury	18 (36)	11 (32)	3 (50)	0.33
Severity of Watershed Injury†
1. Single focal infarction	4 (8)	3 (9)
2. Abnormal signal in anterior or posterior watershed white matter	3 (6)	4 (11)	2 (33)
3. Abnormal signal in anterior or posterior watershed cortex and white matter	5 (10)	2 (6)
4. Abnormal signal in both anterior and posterior watershed zones	5 (10)	1 (3)
5. More extensive cortical involvement	1 (2)	1 (3)	1 (17)
Moderate-Severe Injury on MRI†	11 (23)	6 (17)	2 (33)	0.62

n (%). Analysis across groups was performed using the Chi Squared test.

^†Severity of injury defined using Barkovich grading system as detailed in methods section