θ |
Cross-immunity: reduction in the susceptibility to one strain following natural infection with another strain |
90%; 70%; 50% |
V |
Vaccine valency |
“Bivalent”; “Monovalent” |
L |
Vaccine coverage levels in the 5 age groups |
40% children, 30% adults (baseline scenario); (37%,27%); (30%,22.7%); (24%,18%) (alternative) |
ni |
Population size, age group i. Age groups are (0–4,5–17,18–49,50–64,65+) |
[28] |
cij |
Contact rate between age groups i and j |
[26] |
|
Susceptibility to strain k in age group i |
Drawn uniformly between [0.75,1] for age groups 1–3; 0.65 for age group 4; 0.4 for age group 5 |
w() |
Serial interval distribution |
[29] |
λ |
Scaling parameter for transmission (eq. 1) |
See description following eq. 1
|
D |
Delay (in days) between the introduction of the first infected individuals for strain 2 vs. 1 |
Drawn uniformly between [−35,35] |
E |
Vaccine efficacies against the two strains for the monovalent and the bivalent vaccines |
Vaccine-type strain: 40%/non-elderly, 30%/elderly. Non-vaccine strain: 40%/non-elderly, 30%/elderly (bivalent vaccine); Drawn uniformly between [0,20%]/non-elderly, [0,15%]/elderly (monovalent vaccine) |