Table 2.
Parameters in the transmission process
Parameter | Meaning | Value/Source | |
---|---|---|---|
θ | Cross-immunity: reduction in the susceptibility to one strain following natural infection with another strain | 90%; 70%; 50% | |
V | Vaccine valency | “Bivalent”; “Monovalent” | |
L | Vaccine coverage levels in the 5 age groups | 40% children, 30% adults (baseline scenario); (37%,27%); (30%,22.7%); (24%,18%) (alternative) | |
ni | Population size, age group i. Age groups are (0–4,5–17,18–49,50–64,65+) | [28] | |
cij | Contact rate between age groups i and j | [26] | |
|
Susceptibility to strain k in age group i | Drawn uniformly between [0.75,1] for age groups 1–3; 0.65 for age group 4; 0.4 for age group 5 | |
w() | Serial interval distribution | [29] | |
λ | Scaling parameter for transmission (eq. 1) | See description following eq. 1 | |
D | Delay (in days) between the introduction of the first infected individuals for strain 2 vs. 1 | Drawn uniformly between [−35,35] | |
E | Vaccine efficacies against the two strains for the monovalent and the bivalent vaccines | Vaccine-type strain: 40%/non-elderly, 30%/elderly. Non-vaccine strain: 40%/non-elderly, 30%/elderly (bivalent vaccine); Drawn uniformly between [0,20%]/non-elderly, [0,15%]/elderly (monovalent vaccine) |