Table 2.
Demographic characteristics of the 1339 subjects followed prospectively for outcome of celiac disease autoimmunity or celiac disease.
| Celiac disease autoimmunity | Celiac disease | ||||||
|---|---|---|---|---|---|---|---|
|
| |||||||
| No N=1227 |
Yes N=112 |
p value | No N=1273 |
Yes N=66 |
p value | ||
| Sex N (%) | Female | 569 (46.4) | 64 (57.1) | 0.03 | 595 (46.7) | 38 (57.6) | 0.09 |
|
| |||||||
| HLA genotype N (%) | DR3-DQ2/DR3-DQ2 | 109 (8.9) | 21 (18.8) | <0.0001 | 117 (9.2) | 13 (19.7) | <0.0001 |
| DR3-DQ2/DR4-DQ8 | 337 (27.5) | 40 (35.7) | 353 (27.7) | 24 (36.4) | |||
| DR3-DQ2/X | 224 (18.3) | 26 (23.2) | 230 (18.1) | 20 (30.3) | |||
| DR4-DQ8/DR4-DQ8 | 127 (10.4) | 11 (9.8) | 133 (10.4) | 5 (7.6) | |||
| DR4-DQ8/X | 430 (35.0) | 14 (12.5) | 440 (34.6) | 4 (6.1) | |||
|
| |||||||
| Ethnicity N (%) | Black | 33 (2.7) | 0 (0) | 0.002 | 33 (2.6) | 0 (0) | 0.003* |
| Hispanic | 333 (27.1) | 15 (13.4) | 341 (26.8) | 7 (10.6) | |||
| NHW | 800 (65.2) | 92 (82.1) | 834 (65.5) | 58 (87.9) | |||
| Other | 61 (5.0) | 5 (4.5) | 65 (5.1) | 1 (1.5) | |||
|
| |||||||
| Family history of CD N (%) | Yes | 14 (1.1) | 17 (15.2) | <0.0001 | 16 (1.3) | 15 (22.7) | <0.0001 |
|
| |||||||
| Family history of T1D N (%) | Yes | 75 (6.1) | 10 (8.9) | 0.24 | 80 (6.3) | 5 (7.6) | 0.6 |
SD - standard deviation; T1D – type 1 diabetes
NHW - non-Hispanic white; “other” ethnicity: Asian, biracial or “other” self-reported ethnicities
X = not DR3-DQ2 or DR4-DQ8
*
Indicates Fisher exact test p value instead of chi-square test p value.