Table 4.
Estimated regression coefficients relating child urinary phthalate concentrations to thyroid function at child age 3 yearsa.
| FT4 | ||||
|---|---|---|---|---|
|
| ||||
| Metabolite (loge) | Totalb (n=228) | Girlsb (n=119) | Boys (n=109) | Sex Diff P value |
|
| ||||
| b (95% CI) | ||||
|
| ||||
| MEHP | 0.003 (-0.02, 0.03) | -0.001 (-0.04, 0.04) | 0.01 (-0.02, 0.04) | 0.65 |
| MEHHP | -0.02 (-0.04, 0.01) | -0.04 (-0.07, -0.003)* | 0.01 (-0.03, 0.04) | 0.06 |
| MnBP | --0.04 (-0.07,-0.01)** | -0.06 (-0.09, -0.02)** | -0.01(-0.05, 0.03) | 0.11 |
| MBzP | -0.02 (-0.03, 0.003) | -0.01(-0.04, 0.02) | -0.01 (-0.04, 0.01) | 0.08 |
| MiBP | -0.02 (-0.05, 0.002) | -0.05 (-0.09, -0.01)** | 0.001 (-0.03, 0.04) | 0.0501 |
| MEP | -0.02 (-0.04, 0.01) | -0.04 (-0.07, -0.01)** | 0.01 (-0.02, 0.04) | 0.02 |
| MEOHP | -0.02 (-0.05, 0.01) | -0.04 (-0.07, -0.004)* | 0.01 (-0.03, 0.04) | 0.07 |
| MECPP | -0.01 (-0.04, 0.02) | -0.04 (-0.08, 0.01) | 0.01 (-0.02, 0.06) | 0.06 |
|
| ||||
| Loge(TSH) | ||||
|
| ||||
| Metabolite (loge) | Total (n=229) | Girls (n=120) | Boys (n=109) | Sex Diff P value |
|
| ||||
| b (95% CI) | ||||
|
| ||||
| MEHP | 0.05 (-0.03, 0.12) | 0.02 (-0.07, 0.15) | 0.05 (-0.05, 0.15) | 0.90 |
| MEHHP | 0.004 (-0.07, 0.08) | -0.02 (-0.12, 0.08) | 0.03 (-0.08, 0.13) | 0.56 |
| MBP | -0.02 (-0.10, 0.05) | -0.04 (-0.15, 0.06) | 0.01 (-0.11, 0.12) | 0.54 |
| MBzP | 0.01 (-0.04, 0.06) | -0.01 (-0.08, 0.07) | 0.02 (-0.05, 0.10) | 0.55 |
| MiBP | -0.04 (-0.12, 0.03) | -0.02 (-0.13, 0.08) | -0.06 (-0.17, 0.04) | 0.59 |
| MEP | -0.03 (-0.09, 0.03) | -0.04 (-0.13, 0.05) | -0.02 (-0.11, 0.06) | 0.79 |
| MEOHP | 0.01 (-0.07, 0.08) | -0.03 (-0.12, 0.07) | 0.04 (-0.07, 0.15) | 0.36 |
| MECPP | -0.03 (-0.12, 0.05) | -0.11 (-0.23, 0.01) | 0.04 (-0.08, 0.17) | 0.09 |
Linear models controlled for specific gravity, ethnicity, and child sex (total analyses).
The total and female samples included one subject who did not have FT4 (free thyroxine) but had TSH (thyroid-stimulating hormone) measurement.
For MCOP, the total sample=171, female sample=88, and boy sample=83 subjects.
For MCOP, the total sample=172, female sample=89, and boy sample=83 subjects.
MEHP=mono(2-ethylhexyl) phthalate, MEHHP=mono(2-ethyl-5-hydroxyhexyl) phthalate, MnBP=mono-n-butyl phthalate, MBzP=monobenzyl phthalate, MiBP=mono-isobutyl phthalate, MEP=monoethyl phthalate. MEOHP=mono(2-ethyl-5-oxohexyl) phthalate, MECPP=mono(2-ethyl-5-carboxypentyl) phthalate,
p < 0.05,
p ≤ 0.01.