Table 5.
Estimated regression coefficients relating prenatal urinary phthalate metabolites concentrations to thyroid function at child age 3 yearsa.
| Maternal Metabolite (loge) | Total (n=180) | Girls (n=98) | Boys (n=82) | Sex Diff P Value |
|---|---|---|---|---|
|
| ||||
| FT4 b (95% CI) | ||||
|
| ||||
| MEHP | 0.04 (0.02, 0.07)*** | 0.04 (0.005, 0.07)* | 0.06 (0.02, 0.10)** | 0.44 |
| MEHHP | 0.02 (-0.004, 0.05) | 0.02 (-0.01, 0.05) | 0.03 (-0.02, 0.09) | 0.67 |
| MnBP | -0.01 (-0.05, 0.02) | -0.02 (-0.06, 0.03) | -0.004 (-0.06, 0.05) | 0.70 |
| MBzP | -0.02 (-0.05, 0.005) | -0.02 (-0.06, 0.01) | -0.02 (-0.06, 0.02) | 0.98 |
| MiBP | 0.02 (-0.02, 0.05) | 0.01 (-0.04, 0.05) | 0.03 (-0.03, 0.09) | 0.54 |
| MEP | -0.01 (-0.04, 0.02) | 0.003 (-0.04, 0.04) | -0.02 (-0.07, 0.02) | 0.42 |
| MEOHP | 0.02 (-0.01, 0.05) | 0.02 (-0.01, 0.05) | 0.02 (-0.03, 0.08) | 0.89 |
| MECPP | 0.03 (-0.002, 0.06) | 0.03 (-0.01, 0.07) | 0.03 (-0.02, 0.09) | 0.93 |
|
| ||||
| Maternal Metabolite (loge) | Total (n=181) | Girls (n=99) | Boys (n=82) | Sex Diff P Value |
|
| ||||
| Loge(TSH) b (95% CI) | ||||
|
| ||||
| MEHP | -0.06 (-0.13, 0.001) | -0.04 (-0.12, 0.04) | -0.07 (-0.17, 0.03) | 0.65 |
| MEHHP | -0.06 (-0.13, 0.01) | -0.05 (-0.13, 0.03) | -0.05 (-0.18, 0.07) | 0.99 |
| MnBP | -0.08 (-0.17, 0.01) | -0.12 (-0.23, 0.003) | -0.02 (-0.15, 0.11) | 0.26 |
| MBzP | -0.02 (-0.08, 0.05) | -0.06 (-0.15, 0.03) | 0.03 (-0.07, 0.12) | 0.17 |
| MiBP | -0.06 (-0.15, 0.03) | -0.01 (-0.13, 0.11) | -0.13 (-0.26, 0.01) | 0.20 |
| MEP | 0.04 (-0.03, 0.12) | 0.02 (-0.08, 0.13) | 0.07 (-0.04, 0.18) | 0.54 |
| MEOHP | -0.06 (-0.13, 0.01) | -0.05 (-0.14, 0.04) | -0.05 (-0.18, 0.07) | 0.99 |
| MECPP | -0.06 (-0.14, 0.01) | -0.07 (-0.17, 0.02) | -0.01 (-0.14, 0.12) | 0.46 |
a
Adjusted for child age 3 specific gravity, ethnicity, and child sex (total sample).
FT4 =free thyroxine, TSH=thyroid-stimulating hormone.
MEHP=mono(2-ethylhexyl) phthalate, MEHHP=mono(2-ethyl-5-hydroxyhexyl) phthalate, MnBP=mono-n-butyl phthalate, MBzP=monobenzyl phthalate, MiBP=mono-isobutyl phthalate, MEP=monoethyl phthalate. MEOHP=mono(2-ethyl-5-oxyohexyl) phthalate, MECPP=mono(2-ethyl-5-carboxypentyl) phthalate,
*
p < 0.05,
**
p ≤ 0.01,
***
p ≤ 0.001.