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. Author manuscript; available in PMC: 2018 Aug 1.
Published in final edited form as: DNA Repair (Amst). 2017 Jun 9;56:26–32. doi: 10.1016/j.dnarep.2017.06.004

Figure 3.

Figure 3

Model for Top1-dependent mutagenesis from rNMPs on the lagging strand. Blue represents the leading strand during DNA replication. Red represents the lagging strand primer (squiggle) and DNA Pol α synthesis (straight line). Green represents the region replicated by DNA Pol δ. Misincorporation by DNA Pol δ results in a rNMP residue (red R). If the rNMP persists, in the next cycle it will be on the template strand for leading strand synthesis. Top1 cleavage of the rNMP during leading strand synthesis could result in a slippage mutation event.