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. 2017 Jul 28;7:6829. doi: 10.1038/s41598-017-05748-5

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Sequence analysis of TANC proteins. An overview of TANC family domain architecture is here reported. Both TANC proteins are characterized by a putative P-loop NTPase domain (orange), an Ankyrin repeat containing domain (light teal) and a tetratricopeptide repeat region (blue). For each domain, the sequence boundaries and sequence identity between the two proteins are indicated. Conserved linear motifs are represented as follow: PDZ binding sequences (light blue triangles); PP1 docking motif (RVxF) (orange triangles); degrons (DEG_Nend_Nbox_1 and DEG_SCF_TRCP1_1) (deep teal rectangles); 14_3_3 binding sites (LIG_14-3-3_2) (blue triangles); Homer binding motif (LIG_EVH1_1) (Purple triangle); LATS1 kinase (light orange triangle); NEK2 phosphorylation motif (MOD_NEK2_1) (Teal triangle). Serine-rich regions are represented with green rectangles (TANC1 residues 170-243 and 1659–1689; TANC2 residues 125–189 and 1775–1865). The TANC1 glutamine-rich region (poly-Q) region and TANC2 glutamine/proline rich region (polyP) are in light green and yellow respectively. Alternative TANC protein isoforms are reported in grey. The TANC1 isoform Q9C0D5-2 (1755 residues) is missing the region 122-227. The TANC2 isoform Q9HCD6-2 is longer (2000 residues) due to an insertion at position 1225 (I > IGCQTLPSRPR). Q9HCD6-3 (971 residues) is truncated at residue 97 with different substitution in the region from position 944 to 971 (VDHLDKNGQCALVHAALRGHLEVVKFLI > VLAAQLCCFSSLFLYFRCILFLISSVTS). Q9HCD6-4 (1,010 residues) is truncated at residue 1011 with different substitution in the region from position 1006 to 1010 (IVSYL > VRSRQ).