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. 2017 Jul 28;7:6829. doi: 10.1038/s41598-017-05748-5

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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TANC protein interaction network. TANC interaction partners identified by low throughput data (solid lines), PPI database evidence (thinner lines) or linear motifs prediction. Interactions that are proved only in one paralog, but mediated by binding sites (linear motif or structural domain) that are identical in both proteins, are reported as dotted edges. TANC1 interactors only are colored in light blue; TANC2 interactors only in red: while TANC interactors both are in violet. Interactors are represented with different shapes based on specific molecular function: scaffold proteins (rectangles), protein kinases (rhombus); cytoskeleton proteins (hexagons). TANC proteins are connected with different neuronal regulative proteins, belonging to Planar Cell Polarity signalling (teal outline), Hippo pathway (dark red outline) and glutamate signalling (orange outline).