Table 2.

Predictions for TANC interactors. For each interactor we searched for the putative domain or linear motifs predicted to mediate TANC interaction. We assume that if the known interactor is a class of protein or presents the domain known to bind a predicted TANC linear motif this may be the putative interactor binding site.

TANC	Predicted Interactor		Method	Predicted TANC interacting region
	Name	Domain architecture
1	FBXW11	F-box, 7 WD repeats	TANC1 interactor, Conserved SLiM in IRD	DEG_SCF_TRCP1
				DEG_Nend_Nbox_1
1	YWHAB	14-3-3	TANC2 interactor, same SLiM in TANC2	LIG_14-3-3_2
1	PPP1CA	Ser/Thr phosphatase		DOC_PP1_RVXF_1
1	XPO1/CRM1	Importin_N-term, 10 ARM/HEAT repeat like		TRG_NES_CRM1_1
2	YWHAB	14-3-3	TANC2 interactor, Conserved SLiM in IRD	LIG_14-3-3_2
				LIG_14-3-3_3
2	PPP1CA	Ser/Thr phosphatase		DOC_PP1_RVXF_1
2	NR2C2	ZF- C4, NHR ligand binding		LIG_NRBOX (score 0,3)
2	XPO1/CRM1	Importin_N-term, 10 ARM/HEAT repeat like	TANC2 interactor, Conserved SLiM in P-loop domain	TRG_NES_CRM1_1
2	LATS2	UB associated Kinase, AGC-kinase C-terminal		MOD_LATS_1
2	Homer	WH1/EVH1, Coiled coil	TANC1 interactor	LIG_EVH1_1
2	SCRIB	16 LRR repeats, 4 PDZ	TANC1 interactor, same SLiM in TANC1	LIG_PDZ_Class1
2	FBXW11	F-box, 7 WD repeats		DEG_SCF_TRCP1
				DEG_Nend_Nbox_1
2	Fodrin	23 Spectrin repeats, SH3, 3 EF-hand	TANC1 interactor, same domain in TANC1	ANK and TPR
2	MINK	Kinase, CNH		TPR
2	TNIK	Kinase, CNH		TPR
1	CDK	Kinase	Conserved SLiM in IRD	MOD_CDK_1
1&2	G- Actin	Actin domain		LIG_Actin_WH2_2
1&2	Cyclins	Cyclin, N-terminal		DOC_CYCLIN_1
1&2	MAPK	Kinase		DOC_MAPK_gen_1
1&2	WW domain-containing protein	WW domain		DOC_WW_Pin1_4
1&2	Atg8 protein family	autophagy		LIG_LIR_Gen_1
1&2	CK1	kinase		MOD_CK1_1
1&2	GSK3	kinase		MOD_GSK3_1
1&2	NEK2	kinase		MOD_NEK2_1

SLiM: Short Linear motif; IDR: Intrinsically disordered region. SLiMs are named according to the ELM nomenclature.