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. 2017 Jul 28;7:6836. doi: 10.1038/s41598-017-06342-5

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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The GO and KEGG pathway analysis of DE protein-coding genes in primary monocytes of XLA patients compared to healthy subjects. The significant GO biological process terms (adj.P-value < 0.01) enriched for (a) upregulated genes, and (b) downregulated genes. The number of identified DE protein-coding genes enriched in each GO terms is depicted above bars of x-axis in the figure. The significant KEGG pathway terms enriched for (c) upregulated genes and (d) downregulated genes. Each statistical significance value (adj.p-value) was negative log-10 base transformed.The numbers in the brackets indicated the total number of genes available in the KEGG database for each pathway terms. The number of identified DE protein-coding genes enriched in each KEGG pathways is depicted above bars of x-axis in the figure.