Table 3.
The downregulated genes involved in immune-related pathways in primary monocytes of XLA patients compared to healthy subjects.
| Pathway Terms | P-value | Adj.P-value | Gene Name |
|---|---|---|---|
| Fc gamma R-mediated phagocytosis | 1.10E-07 | 2.60E-06 | FCGR2A, ASAP1, GAB2, DOCK2, DNM1L, INPP5D, MAPK1, MAP2K1, PAK1, PIKFYVE, PIK3CG, PIK3R5, PLCG1, PRKCB, PRKCE, PTPRC, SYK, LYN, VASP, VAV3, PIK3R1, RAF1, AKT2 |
| Chemokines signaling pathway | 4.70E-07 | 9.30E-06 | CXCL16, CXCR4, CXCR1, CXCR2, JAK2, ROCK2, ADCY6, ADCY7, ADCY9, ADRBK2, DOCK2, FOXO3, GRB2, GNB4, GNG12, GNG2, MAPK1, MAP2K1, NRAS, PAK1, PIK3CG, PIK3R1, PIK3R5, PRKCB, PRKX, STAT2, STAT5B, ROCK1, SOS1, SOS2, BRAF, VAV3 |
| Toll-like receptors signaling pathway | 3.10E-06 | 4.30E-05 | TLR1, TLR5, TLR2, TLR4, TLR6, TLR7, TBK1, IKBKE, JUN, MAPK1, MAP2K1, MAP2K4, MYD88, PIK3CG, PIK3R1, PIK3R5, FOS |
| MTOR signaling pathway | 5.20E-05 | 3.80E-04 | MTOR, RICTOR, HIF1A, MAPK1, PIK3CG, PIK3R1, PIK3R5, RPS6KA3, TSC1, ULK2, BRAF |
| Jak-STAT signaling pathway | 1.20E-04 | 7.10E-04 | CREBBP, CBL, EP300, JAK1, JAK2, CSF2RB, GRB2, IL10RA, IL13RA1, IL6R, IL6ST, PIK3CG, PIK3R1, PIK3R5, PRLR, STAT2, STAT5A, STAT5B, SOS1, SOS2, SOCS4, SOCS7 |
| MAPK signaling pathway | 4.30E-04 | 2.10E-03 | RAPGEF2, ATF2, DUSP1, DUSP6, FLNB, GRB2, GNA12, GNG12, HSPA1A, JUN, MAPK1, MAP2K1, MAP2K4, MAP3K1, MAP4K4, NRAS, PAK1, PRKCB, PRKX, RPS6KA3, SOS1, SOS2, TGFBR1, FOS, BRAF |
| ErbB signaling pathway | 5.10E-04 | 2.40E-03 | CBL, EREG, GRB2, JUN, MTOR, MAPK1, MAP2K1, MAP2K4, NRAS, PAK1, PIK3CG, PIK3R, PIK3CG, PIK3R, PIK3R5, PLCG1, PRKCB, STAT5A, STAT5B, SOS1, SOS2, ABL2, BRAF |
| Insulin signaling pathway | 8.30E-04 | 3.80E-03 | CBL, GRB2, INPP5D, IRS2, MTOR, MAPK1, MAP2K1, NRAS, PDE3B, PIK3CG, PIK3R1, PIK3R5, PRKCI, PRKX, PTPRF, SOS1, SOS2, SOCS4, TSC1, BRAF |
| Endocytosis | 1.00E-03 | 4.50E-03 | ARAP2, ASAP1, ACAP2, CBL, DNAJC6, EHD3, IQSEC1, RAB11, FIP1, ADRBK2, CXCR4, CLTCL1, DNM1L, EPN2, HSPA1A, CXCR1, CXCR2, LDLR, NEDD4, PIKFYVE, PRKCI, RNF41, SMAP2, TGFBR1, VPS36 |
| Regulation of actin cytoskeleton | 2.20E-03 | 9.60E-03 | IQGAP1, IQGAP2, ARHGEF12, ROCK2, ACTN1, CYFIP1, FGFR1, FN1, GNA12, GNA13, GNG12, ITGA4, ITGAV, ITGB1, MAPK1, MAP2K1, NRAS, PAK1, PIKFYVE, PIK3CG, PIK3R1, PIK3R5, PPP1R12A, ROCK1, SSH2, SOS1, SOS2, BRAF, VAV3 |