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. 2017 Jul 28;7:6835. doi: 10.1038/s41598-017-07047-5

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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In vivo Raman spectroscopy system for cervical assessment during pregnancy. (A) Illustration showing the placement of the Raman spectroscopy fiber optic probe against the ectocervix of the mouse. (B) Mouse cervix visualized using a speculum. (C) In vivo Raman spectroscopy during measurement of mouse cervix. (D) Raman spectroscopy fiber optic probe. (E) Image of in vivo Raman spectroscopy system. Average Raman spectra from different time points during pregnancy in WT (F) and Cox-1 KO (G) mice. Gray boxes indicate regions that were highlighted in Figs 3–4.