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. 2017 Jul 28;7:6753. doi: 10.1038/s41598-017-07075-1

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Evaluation of malignant and benign breast nodules by SWE and by histopathological staining for collagen and Kindlin-2 expression. (a1) (b1) Representative SWE images of malignant and benign breast nodules. (a2) (b2) Representative images from Sirius red staining (×200) show expression of collagen in malignant and benign breast nodules, respectively. (c2) Quantitative analysis shows that the average intensity of collagen in malignant breast nodules was significantly higher than that in benign breast nodules. (a3) (b3) Representative images of immunohistochemical staining (×200) show expression of Kindlin-2 in malignant and benign breast nodules, respectively. (c3) Quantitative analysis shows that the average expression (by integrated optical density of positive reactions) of Kindlin-2 in malignant breast nodules was significantly higher than that in benign breast nodules. Values are means ± SD. Comparisons between two groups were made using Student’s t-test. *p < 0.05, **p < 0.01. SWE, shear wave elastography; SD, standard deviation.