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. 2017 Jul 28;7:6753. doi: 10.1038/s41598-017-07075-1

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Expression levels of p-FAK and p-Smad2 in malignant nodules with or without lymph nodes metastasis, and in benign nodules. (a1) (b1) Representative images of immunohistochemical staining (×200) show expression of p-FAK in malignant and benign breast nodules. (c1) Quantitative analysis shows that the average expression (by integrated optical density of positive reactions) of p-FAK in malignant breast nodules was significantly higher than that in benign breast nodules. (a2) (b2) Representative images of immunohistochemical staining (×200) show expression of p-Smad2 in malignant and benign breast nodules. (c2) Quantitative analysis shows that the average expression (by integrated optical density of positive reactions) of p-Smad2 in malignant breast nodules was significantly higher than that in benign breast nodules. (d) The p-FAK expression of malignant breast nodules with lymph node metastasis was significantly higher than that without lymph node metastasis. (e) The p-Smad2 expression of malignant breast nodules with lymph node metastasis was significantly higher than that without lymph node metastasis. Values are means ± SD. Comparisons between two groups were made using Student’s t-test. *p < 0.05, **p < 0.01. SD, Standard deviation.