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. 2017 Jul 28;7:6792. doi: 10.1038/s41598-017-07219-3

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Effects of subcutaneous TNS on CCI-induced TBI. (A) Representative changes in CBF, PbrO₂, brain temperature and MAP with intermittent TNS. (B) CBF increased significantly at 15 min, 30 min and 60 min after CCI. (C) PbrO₂ increased significantly at 30 min and 60 min after CCI. (D) Brain temperature changes increased significantly at 60 min after CCI. (E) MAP increased significantly at 30 min and 60 min after CCI. Data were expressed as mean ± SD and analyzed using student’s t test. ^#p < 0.05 vs CCI-induced TBI, n = 6~7/group. Red: TBI + TNS; Black: TBI.