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. 2017 Jul 28;7:6792. doi: 10.1038/s41598-017-07219-3

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Effects of subcutaneous TNS on brain damage. (A) Brain edema decreased significantly at 24 h after CCI-induced severe TBI. (B) TNS ameliorated blood-brain barrier (BBB) disruption. (C) Lesion volume decreased significantly with TNS treatment. Data were expressed as mean ± SD and compared by one-way ANOVA and Student-Newman-Keuls test. ^#p < 0.05 vs sham, ^*p < 0.05 vs CCI-induced TBI, n = 6/group.