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. 2017 Jul 28;7:6789. doi: 10.1038/s41598-017-06680-4

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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KLK family sequence similarity. (a) Human KLK full length protein sequences (UniProtKB) were aligned using Clustal Omega. Phylogram indicated high sequence similarity between KLK7, KLK4 and KLK5 (in box). (b) KLK4, 5 and 7 sequence alignment represents high sequence similarity adjacent to the catalytic triad residues (His57, Asp102 and Ser195 in red). N-termini of mature KLKs starting at Ile16 is shown in bold letters. “*”, a single, fully conserved residue; “:”, conservation between groups of strongly similar properties-scoring >0.5^; “ . ”, conservation between groups of weakly similar properties-scoring ≤0.5^; ^Gonnet PAM250 matrix. (c) mKLK4 showed residual activity against d-VLR-AFC peptide substrate compared to the dmKLK4.