Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2017 Jul 28;7:6766. doi: 10.1038/s41598-017-06130-1

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

A comparison of transmission reduction activity (reduction in mean oocyst intensity, TRA) for anti-Pfs230 (panels A, B and C) and anti-Pfs25 (panels D, E and F) antibodies. In all panels point shading denotes exposure in oocysts/mosquito (darkest shades match highest exposures). Point size indicates the mean number of dissected mosquitoes dissected. (A and D) Predicted best fit relationship between TRA and antibody titer with 95% confidence intervals showing the uncertainty around the best fit line. The dashed line shows the 95% confidence intervals for single TRA estimates. B and E: Best fit model showing (with 95% confidence intervals) how TRA does not change with parasite exposure. Point and area shading feature antibody titer (dark colors match for 40 µg/ml IgG titers and light colors, for 4 µg/ml). (C and F) Model predictions of how transmission blocking efficacy (TBA) changes with TRA and parasite exposure. Contours show how the best fit models in Fig. 1 can be used to convert TRA into TBA according to the level of exposure. These model predictions are then compared to the true TBA results (data points).