Table 1.
Concentration of antigen-specific IgG necessary to achieve 99%, 80% and 50% target TBA with anti-Pfs230 and anti-Pfs25 antibodies, in hosts with different levels of parasite exposures: 1 oocysts/mosquitoes (low), 5 oocysts/mosquito (medium), 20 oocysts/mosquito (high).
| Target TBA | |||||
|---|---|---|---|---|---|
| 99% TBA | 80% TBA | 50% TBA | |||
| Parasite exposure | 1 | Anti-Pfs230 | 3.29 µg/ml | 2.33 µg/ml | 1.18 µg/ml |
| Anti-Pfs25 | 7.50 µg/ml | 4.89 µg/ml | 2.81 µg/ml | ||
| 5 | Anti-Pfs230 | 4.07 µg/ml | 2.89 µg/ml | 1.45 µg/ml | |
| Anti-Pfs25 | 10.37 µg/ml | 6.89 µg/ml | 3.75 µg/ml | ||
| 20 | Anti-Pfs230 | 9.54 µg/ml | 6.43 µg/ml | 3.14 µg/ml | |
| Anti-Pfs25 | / | 23.19 µg/ml | 8.18 µg/ml | ||
This table is intended to show how future human antibodies can be directly compared as avidity between mouse and human antibodies may vary.