Table III.

The Particle Size Needed for the Model Compounds to Dissolve Completely in 3.32 h, Based on the Maximum Dose Administered for Each Compound

Compound	Dose (mg)	1 μm	10 μm	25 μm	50 μm	100 μm	Size (μm)
Cinnarizine	25	Yes	No	No	No	No	2.0
Fenofibrate	200	Yes	No	No	No	No	3.1
Aprepitant	125	Yes	No	No	No	No	7.2
Felodipine	10	Yes	Yes	No	No	No	11.3
Tadalafil	20	Yes	Yes	No	No	No	13.5
Indomethacin	100	Yes	Yes	Yes	Yes	Yes	600.0

The maximum doses were obtained from the Swedish Physician Desk Reference. Material being completely dissolved=yes; not dissolved=no. Size provided in right column shows which particle size is needed to allow all material to dissolve within 3.32 h