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Phosphorylation of Sox2 regulates its function in the transition between cell states. A model of the functions of Sox2 in self-renewal of stem cells and during neurogenesis is shown. Dark blue ovals, full-length Sox2; light blue ovals with dotted outline, full-length Sox2 with reduced binding; cS, cleaved Sox2; empty halved oval with dashed outline, cS with no binding.
