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let-7 transgenic mice show tortuous retinal vessels. (A) Representative angiogram pictures shown tortuous retinal vessels in let-7-Tg mice aged 2 to 12 months but not in WT littermates. (B) ICAM-2 and α-SMA staining of 4-month-old WT and let-7-Tg retinas. Normal smooth muscle coverage but tortuous arteries were observed in let-7 transgenic retinas.
