FIG 2.

S302A mutation changes liver morphology and liver functions. (A) Examination of body weight and levels of total fat and leanness in CUGBP1-S302A mice. *, P < 0.05. (B) Livers of S302A mice have increased numbers of enlarged hepatocytes with accumulated fat droplets. H&E staining was performed with 2-month-old WT and S302A mice. Bar graphs show percentages of large hepatocytes containing fat droplets. (C) S302A mice have increased triglyceride, VLDL, and ALT levels in blood serum, but levels of glucose are reduced. (D) Glucose tolerance test.