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Model summarizing the immunomodulatory functions of HSV-1 UL46. HSV-1 UL46 interacts with both STING and TBK1 via separate domains. Most likely these interactions abrogate the functions of STING and of TBK1. UL46 also influences the accumulation of IFI16. Other partners of UL46 include members of the Src family kinases (21–23).
