TABLE 2.
Group | Monkey | DENV2 load (RNA copies/ml) on postchallenge daya: |
|||||
---|---|---|---|---|---|---|---|
2 | 3 | 4 | 5 | 6 | 10 | ||
Vaccinated | r09084 | <20 | <20 | <20 | <20 | <20 | <20 |
r10019 | <400 | <400 | <400 | 1,120 | <400 | 3,360 | |
r12078 | <20 | <20 | <20 | <20 | <20 | ND | |
rhBE94 | 15,900 | 17,700 | 33,300 | 88,400 | 18,200 | <20 | |
Control | rh2313 | 1,560 | 760 | 730 | 3,230 | 14,300 | 28,600 |
r08037 | 520 | 610 | <400 | <400 | 4,410 | 5,950,000 |
Viral loads were quantified via quantitative real-time PCR. Monkeys were challenged 19 weeks after inoculation of recombinant RRV. <20 indicates that the viral load was below the limit of detection of 20 DENV2 RNA copies/ml plasma; <400 indicates that the monkeys tested positive but that the viral load was below the limit of quantitation; ND, not done.