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Schematic representation of cellular and viral proteins binding to the cloverleaf (stem-loop I) of positive-strand viral RNAs. Stem-loop I RNA is organized into stem a and stem-loops b, c, and d. Cellular PCBP2 and the viral protein 3CDpro bind to the cloverleaf at the 5′ end of positive-strand RNA to form a ribonucleoprotein complex required for the initiation of both negative-strand and positive-strand RNA synthesis.
