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Antiviral activity of representative compounds against drug-resistant HBV mutants
| Compound | Mean EC50 ± SD (μM)a |
||||
|---|---|---|---|---|---|
| NUC sensitive, WT | ADV resistant |
3TC resistant, rtM204I | 3TC/ETV resistant, rtL180M, rtM204V, rtT184G, rtS202I | ||
| rtA181V | rtN236T | ||||
| 3TC | 0.029 ± 0.0007 | 0.110 ± 0.007 | 0.064 ± 0.09 | >10.000 | >10.000 |
| ETV | 0.001 ± 0.0001 | 0.002 ± 0.001 | 0.0002 ± 0.0001 | 0.055 ± 0.0007 | 1.100 ± 0.140 |
| BA-38017 | 1.04 ± 0.01 | 1.51 ± 0.18 | 1.91 ± 0.07 | 0.75 ± 0.07 | 1.59 ± 0.07 |
From duplicate experiments.
