TABLE 3.
Antiviral activities of representative compounds against drug-resistant HBV mutants
| Plasmid (GenBank accession no.) | Genotype | Mean EC50 ± SD (μM)a |
||||
|---|---|---|---|---|---|---|
| 3TC | ETV | ADV | BA-38017 | ENAN-34017 | ||
| pHY536207 (AY220698.1) | B | 0.040 ± 0.004 | 0.0002 ± 0.00003 | 0.017 ± 0.004 | 0.470 ± 0.012 | 0.029 ± 0.003 |
| pHY634 (AY220697.1) | B | >3.000 | 0.007 ± 0.004 | 0.028 ± 0.011 | 0.390 ± 0.047 | 0.021 ± 0.007 |
| pHY6923 (FJ518812.1) | B | 0.039 ± 0.005 | 0.0003 ± 0.00003 | 0.065 ± 0.009 | 0.420 ± 0.051 | 0.046 ± 0.007 |
| pHY6945 (FJ518813.1) | C | 0.032 ± 0.005 | <0.0002 | 0.057 ± 0.009 | 1.500 ± 0.565 | 0.180 ± 0.038 |
a
From quadruplicate experiments.