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. 2017 Jul 27;91(16):e00441-17. doi: 10.1128/JVI.00441-17

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Copyright © 2017 Ruiz-Riol et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license.

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FIG 3 — Plasma levels of Wnt/β-catenin pathway proteins are associated with IL-17 signaling in chronic HIV infection. (A) Differential relative plasma levels of Wnt/β-catenin inhibitor 1 (WIF1) and activator (WNT1) factors between HIV-High (light gray circles) and HIV-Low (open circles) detected in the communicome screens. (B) Inverse relationship between relative plasma levels of WNT1 (x axis) and WIF1 (y axis) across all individuals. (C) Inverse correlation between relative plasma levels of WNT1 (x axis) and IL-17A (y axis) in HIV-High (light gray circles) and HIV-Low (open circles) subjects. (D) Positive association between relative plasma levels of WNT1 (x axis) and IL-27 (y axis) detected in HIV-High (light gray circles) and HIV-Low (open circles) subjects. The Mann-Whitney test was applied for group comparisons and the Spearman rank test for correlation analyses. P values of <0.05 were considered significant.