FIG 3.
Comparison of pathogenesis in suckling mice, adult mice, and pigs after infection with chimeric FMDVs. Suckling mice (n = 10) and adult mice (n = 3) were challenged with the recombinant FMDV (105.0 TCID50/0.1 ml) intraperitoneally. Pigs (n = 2) were challenged with the virus (105.0 TCID50/0.1 ml) intradermally in each footpad. (A) Change in adult mouse body weight (percentage) over time after chimeric FMDV challenge. (B) Viremia on the third day after chimeric FMDV challenge in adult mice. P values of <0.01 (**) and <0.001 (***) were regarded as significant or highly significant. (C) Survival rate of suckling mice after challenge with recombinant FMDVs and the O Manisa wild type (Om-Wild type). (D) Correlation (r) of the relationships between porcine clinical score (CS), body weight loss (BWL) (percent) of adult mice, and fatality rate (FR) (percent) of suckling mice on days 3, 4, and 5 after challenge with eight tested viruses of all serotypes.