FIG 3.

Varying clonal stability of CTL responses over time. An example of a CTL response exhibiting changing clonal composition over time is shown (A). The response to AK9 in subject S00009 was comprised of clonal expansions in BV7 (within peak 3) and BV11 (peak 4) at the baseline evaluation, but then clonal expansions in BV6a (peak 6), BV10 (peak 5), and BV28 (peak 5) 114 weeks later. (B) In contrast, another response (against the GY9 epitope) in the same person showed a relatively stable clonal composition over the same span of time.