Table 2.
Mean and standard deviation of metabolic parameters
| Equal | Improved | Worse | Timea | Subgroupb | Interactionc | ||||
|---|---|---|---|---|---|---|---|---|---|
| T0 | T48 | T0 | T48 | T0 | T48 | ||||
| Systolic blood pressure, mmHg | 125.0 ± 14.9 | 125.4 ± 14.0 | 122.8 ± 15.4 | 124.6 ± 16.1 | 121.4 ± 17.3 | 123.1 ± 15.8 | 0.097 | 0.432 | 0.534 |
| Diastolic blood pressure, mmHg | 78.0 ± 9.6 | 78.5 ± 12.1 | 77.2 ± 8.9 | 78.8 ± 10.2 | 75.8 ± 9.9 | 77.0 ± 9.7 | 0.114 | 0.557 | 0.684 |
| Total cholesterol, mg/dL | 190.8 ± 43.2 | 191.6 ± 42.4 | 182.7 ± 47.7 | 203.3 ± 54.3 | 187.3 ± 51.8 | 204.9 ± 44.9 | 0.141 | 0.646 | 0.020 |
| Triglycerides, mg/dL | 159.5 ± 90.2 | 167.2 ± 145.9 | 146.5 ± 81.6 | 142.0 ± 74.6 | 136.1 ± 70.4 | 142.4 ± 98.2 | 0.958 | 0.384 | 0.980 |
| LDL-cholesterol, mg/dL | 111.1 ± 37.1 | 114.0 ± 33.6 | 103.7 ± 41.4 | 125.9 ± 38.9 | 119.1 ± 47.3 | 115.4 ± 35.8 | 0.009 | 0.872 | 0.007 |
| Fasting glucose, mg/dL | 92.5 ± 21.3 | 91.7 ± 30.3 | 91.5 ± 20.7 | 81.9 ± 9.2 | 96.4 ± 25.6 | 89.3 ± 15.8 | 0.176 | 0.117 | 0.257 |
| CD4, % | 30.2 ± 9.8 | 37.1 ± 54.3 | 28.1 ± 10.9 | 29.2 ± 10.5 | 32.1 ± 6.3 | 33.2 ± 7.9 | 0.514 | 0.581 | 0.748 |
| CD4+, cell/μL | 651.4 ± 295.8 | 688.0 ± 294.7 | 659.5 ± 344.0 | 767.1 ± 398.1 | 663.0 ± 281.2 | 755.4 ± 323.4 | 0.001 | 0.675 | 0.376 |
| CD4/CD8 ratio | 0.8 ± 0.5 | 0.9 ± 0.4 | 0.8 ± 0.5 | 0.8 ± 0.4 | 0.9 ± 0.3 | 1.0 ± 0.4 | 0.208 | 0.699 | 0.178 |
| Creatinine, mg/dL | 0.9 ± 0.2 | 0.9 ± 0.3 | 0.8 ± 0.2 | 0.9 ± 0.2 | 0.8 ± 0.1 | 0.8 ± 0.1 | 0.600 | 0.359 | 0.503 |
| Uric acid, mg/dL | 5.3 ± 2.0 | 5.3 ± 1.5 | 5.1 ± 1.2 | 5.1 ± 1.5 | 5.3 ± 2.3 | 4.8 ± 0.9 | 0.656 | 0.608 | 0.733 |
| MDRD glomerular filtration rate, mL/min/1.73 m2 | 100.7 ± 24.4 | 101.6 ± 23.4 | 89.0 ± 55.2 | 90.5 ± 27.6 | 95.7 ± 17.3 | 91.9 ± 16.5 | 0.991 | 0.728 | 0.870 |
| Albuminemia, g/dl | 4.4 ± 0.4 | 4.4 ± 0.3 | 4.3 ± 0.4 | 4.4 ± 0.4 | 4.4 ± 0.3 | 4.5 ± 0.3 | 0.217 | 0.487 | 0.725 |
| GOT/GPT ratio | 0.8 ± 0.3 | 0.9 ± 0.3 | 0.9 ± 0.4 | 0.9 ± 0.3 | 1.0 ± 0.3 | 1.2 ± 0.7 | 0.004 | 0.021 | 0.060 |
| Cystatin C, mg/L | 0.8 ± 0.2 | 0.9 ± 0.2 | 0.8 ± 0.2 | 0.9 ± 0.2 | 0.7 ± 0.1 | 0.8 ± 0.1 | <0.001 | 0.612 | 0.250 |
aProbability that values are influenced by time. For each variable, the difference has been tested between the mean of the T0 and the mean of the T48, independently of subgroup
bProbability that values are influenced by the change of state of microalbuminuria. For each variable, the difference has been tested between the means of the subgroups, independently of time
cProbability that the effect of the treatment time is different in the three subgroups (equal, improved and worse)
p values in bold suggest significant values