Table 2.

Relationship of demographic and clinical characteristics and cerebrospinal fluid (CSF) cytokine concentrations in 69 Ugandan children with cerebral malaria to CSF (a) KYNA and (b) kynurenine concentration

Characteristic	Spearman’s rho value (95% CI)	P
a
Age	−0.45 (−0.62,−0.24)	0.0001
Sex	−0.06 (−0.29, 0.18)	0.63
Parasite density	−0.01 (−0.25, 0.24)	0.94
Lactate level	0.14 (−0.11, 0.37)	0.26
Malaria retinopathy	0.15 (−0.09, 0.37)	0.23
CSF IFN-γ	0.22 (−0.07, 0.47)	0.12
CSF TNF	0.27 (0.03, 0.48)	0.03
b
Age	−0.34 (−0.53, −0.11)	0.004
Sex	−0.003 (−0.24, 0.24)	0.98
Parasite density	−0.09 (−0.33, 0.16)	0.46
Lactate level	0.26 (0.01, 0.47)	0.04
Malaria retinopathy	0.06 (−0.18, 0.30)	0.61
CSF IFN-γ	0.22 (−0.06, 0.48)	0.11
CSF TNF	0.30 (0.05, 0.50)	0.01