Table 4.

Relationship of (a) KYNA and (b) kynurenine levels with cognitive outcomes at 12-month follow-up in Ugandan children with cerebral malaria

Cognitive outcome	β coefficient (95% CI)a	P value
a
Age <5 years, n = 40
Overall cognitive ability	−0.6 (−2.6, 1.5)	0.57
Attention	−0.2 (−0.7, 1.2)	0.60
Age ≥5 years, n = 22
Overall cognitive ability	−0.5 (−2.8, 1.8)	0.63
Attention	−2.1 (−4.9, −0.2)	0.03
b
Age <5 years, n = 40
Overall cognitive ability	−0.3 (−2.5, 2.0)	0.82
Attention	−0.5 (−1.5, 0.5)	0.29
Age ≥5 years, n = 22
Overall cognitive ability	−1.8 (−3.7, 0.05)	0.056
Attention	−2.5 (−4.0, −1.1)	0.003

Log-transformed (base 10)

^aMultiple linear regression, adjusted for age and lactate level