Table 4.

Joint effect of rs9642758 and rs10503970 locus on Chromosome 8^a

	SNPmain				Pbmain				GxE Interaction
Cohort	β	95% CI		p	β	95% CI		p	β	95% CI		p
Mental composite scores
rs9642758 (minor allele: A; major allele as reference: G)
Mexico	−8.16	−13.42	−2.90	0.0025	−1.93	−3.52	−0.34	0.0174	7.66	3.35	11.97	4.74E-04
Bangladesh	−3.41	−6.22	−0.60	0.0176	−0.44	−1.44	0.55	0.3821	2.93	0.91	4.95	0.0044
Meta												8.79E-06
rs10503970 (minor allele: A; major allele as reference: G)
Mexico	−7.45	−13.42	−1.47	0.0147	−1.77	3.34	−0.19	0.0283	7.32	2.85	11.78	0.0013
Bangladesh	−3.52	−5.95	−1.08	0.0048	−0.49	−1.52	0.53	0.3452	2.36	0.69	4.04	0.0056
Meta												2.57E-05
rs9642758 & rs10503970
Mexico	−6.13	−10.22	−2.05	0.0034	−2.33	−3.77	−0.88	0.0017	5.72	3.01	8.44	3.41E-05
Bangladesh	−3.82	−5.89	−1.75	3.20E-04	−1.23	−2.43	−0.03	0.0438	2.88	1.53	4.24	3.06E-05
Meta												4.38E-09
Motor composite scores
rs9642758 (minor allele: A; major allele as reference: G)
Mexico	−2.62	−5.17	−0.08	0.0435	−0.21	−0.98	0.56	0.5948	2.82	0.31	5.33	0.0271
Bangladesh	−1.13	−2.53	0.28	0.1153	0.48	−0.02	0.97	0.0597	0.90	−0.04	1.83	0.0587
Meta												0.0041
rs10503970 (minor allele: A; major allele as reference: G)
Mexico	−4.46	−7.35	−1.57	0.0026	−0.22	−0.98	0.54	0.5630	3.51	0.90	6.11	0.0081
Bangladesh	−1.48	−2.69	−0.27	0.0166	0.39	−0.12	0.91	0.1306	0.94	−0.10	1.98	0.0754
Meta												0.0021
rs9642758 & rs10503970
Mexico	−2.68	−4.84	−0.52	0.0154	−0.42	−1.13	0.29	0.2428	2.36	0.51	4.22	0.0121
Bangladesh	−1.52	−2.62	−0.42	0.0071	0.16	−0.38	0.69	0.5673	1.04	0.30	1.78	0.0056
Meta												1.87E-04

SNP Single-nucleotide polymorphism, MAF minor allele frequency

^aModel: Y = β₀ + β₁*G + β₂*E(Pb) + β₃*G*E + γ*Z, adjusted for child’s gender, child’s age at time of neurodevelopment testing, gestational age, parity, maternal education (binary), environmental tobacco smoke exposure (binary), and first two principal components of population stratification