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. 2017 Jul 28;17:374. doi: 10.1186/s12906-017-1874-1

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© The Author(s). 2017

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 3 — Effect of SC-E1 on the production of pro-inflammatory mediators and cytokines in LPS-stimulated RAW 264.7 macrophages. a Effect of SC-E1 on nitrite production in LPS-stimulated RAW 264.7 cells. The cells were stimulated with 1 μg/ml of LPS, in the absence or presence of various concentrations (10, 50, 100, 300 μg/ml) of SC-E1 for 24 h. Nitrite production by LPS treated macrophages was measured using Griess reagent. Effects of SC-E1 on the secretion of (b) PGE₂, (c) IL-1β (d), and TNF-α. (Significant compared to the control, ^### p < 0.001, significant as compared to LPS alone, *p < 0.05 and ***p < 0.001)