Table 1.
Routine and specialised haemostatic parameters by experimental group at selected time points
| Ventilation only | S-ALI control | ECMO control | S-ALI + ECMO | |||||
|---|---|---|---|---|---|---|---|---|
| B | 24 h | B | 24 h | B | 24 h | B | 24 h | |
| Full blood examination | ||||||||
| WCC, ×109/L | 9.8 (3.1) | 10.2 (2.2) | 7.8 (2.1) | 21.8 (8.3)a | 7.0 (2.2) | 7.9 (1.7)a | 6.6 (1.2) | 9.1 (3.8)a |
| RCC, ×1012/L | 8.7 (0.68) | 6.2 (0.6) | 8.5 (0.78) | 8.9 (1.36)a | 8.0 (1.2) | 4.8 (0.54)a | 8.3 (0.87) | 7.3 (1.2) |
| Hb, g/L | 97.8 (9.1) | 70.3 (6.1) | 96.1 (9.4) | 99.1 (12)a | 89.3 (12) | 54.3 (5.4)a | 93.4 (11) | 83.5 (12) |
| Hct | 0.28 (0.02) | 0.20 (0.02) | 0.28 (0.03) | 0.29 (0.04)a | 0.26 (0.04) | 0.16 (0.01)a | 0.28 (0.03) | 0.24 (0.04) |
| PLT, ×109/L | 341 (173) | 190 (110) | 355 (186) | 203 (111) | 471 (95) | 260 (80) | 364 (140) | 199 (60) |
| Routine coagulation tests | ||||||||
| PT, seconds | 14.5 (1) | 17.3 (1) | 15.9 (1.1) | 34.4 (5.4)a | 12.9 (0.6) | 17.4 (2.1) | 14.3 (0.9) | 35 (6.7)a |
| aPTT, seconds | 33 (6) | 139 (76) | 31 (6) | 165 (42) | 26 (4.6) | 122 (64) | 30 (6) | 158 (57) |
| Fibrinogen, g/L | 2.5 (0.54) | 3.5 (0.13) | 2.1 (0.62) | 2.5 (0.34)a | 2.9 (0.47) | 2.6 (0.16)a | 3.0 (0.97) | 1.5 (0.5)a |
| d-dimer, ng/ml | 215 (85) | 198 (70) | 146 (44) | 139 (82) | 435 (192) | 343 (217) | 406 (213) | 213 (136) |
| TCT, seconds | 13 (0) | 21 (7) | 13 (0) | 81 (84) | 12 (1) | 156 (81) | 13 (1) | 44 (69) |
| Specialised coagulation tests | ||||||||
| FVIII, % | 1531 (413) | 1390 (414) | 1347 (417) | 1544 (238) | 891(235) | 408 (51)a | 904 (166) | 531 (242)a |
| FXII, % | 103 (17.7) | 75 (10) | 96 (30.9) | 29 (11.5)a | 151 (37.7) | 67 (12.4) | 107 (20.2) | 16 (6.7)a |
| Protein C, % | 21.5 (2.5) | 21.5 (1.3) | 21 (7.4) | 12.1 (3.2) | 55 (13.4) | 50 (11.2) | 46 (11.4) | 14 (4.5)a |
| vWAg, % | 136 (22.3) | 130 (25.8) | 96 (31.9) | 140 (18.2) | 94 (47.6) | 88 (10.9)a | 129 (30) | 96 (25.3)a |
| AT, % | 85.8 (7.3) | 58.3 (6.6) | 84.1 (3.9) | 27.1 (3.2)a | 93.7 (8.8) | 62.7 (6) | 92.3 (1.9) | 22 (4.3)a |
Abbreviations: aPTT Activated partial thromboplastin time, AT Anti-thrombin, B baseline, ECMO Extracorporeal membrane oxygenation, FVIII Factor VIII, FXII Factor XII, Hb Haemoglobin, Hct Haematocrit, PLT Platelets, PT Prothrombin time, RCC Red cell count, S-ALI Smoke-induced acute lung injury, TCT Thrombin clotting time, vWAg von Willebrand factor antigen, WCC White cell count
Data are presented as mean (±SD)
a P < 0.05 over time vs ventilation only