Table 2.
Predicted marginal mean values and 95% CIs for haemostatic parameters, by experimental group and overall Wald P values derived from mixed effects regression models
| Ventilation only | S-ALI control | ECMO control | S-ALI + ECMO | Wald P value | |
|---|---|---|---|---|---|
| WCC | 8.4 (6.8–9.9) | 5.5 (4.4–6.7) | 6.0 (4.8–7.2) | 4.9 (3.8–6) | 0.004 |
| RCC | 6.9 (6.3–7.5) | 7.3 (6.9–7.8) | 5.0 (4.5–5.5) | 6.2 (5.7–6.6) | <0.001 |
| Hb | 75 (70–81) | 87 (83–91) | 55 (50–60) | 73 (69–77) | <0.001 |
| PLT | 195 (121–269) | 248 (188–309) | 238 (185–290) | 207 (155–260) | 0.609 |
| PT | 16 (13.4–18.6) | 20 (17.7–22.2) | 18.9 (16.7–21) | 23.7 (22.1–25.3) | 0.007 |
| aPTT | 113 (89–137) | 117 (96–139) | 100 (80–119) | 124 (106–141) | 0.164 |
| TCT | 68 (36–99) | 96 (69–122) | 159 (133–184) | 104 (82–127) | 0.063 |
| d-dimer | 211 (98–324) | 157 (71–242) | 332 (232–432) | 276 (195–358) | 0.852 |
| Fib(C) | 2.7 (2.4–3) | 2.0 (1.7–2.3) | 2.2 (1.9–2.4) | 1.4 (1.2–1.6) | <0.001 |
| FVIII | 1161 (1016–1307) | 1082 (956–1208) | 529 (410–647) | 505 (415–595) | <0.001 |
| FXII | 70 (59–81) | 22 (13–31) | 63 (55–72) | 13 (6–20) | <0.001 |
| vWAg | 135 (120–151) | 130 (118–142) | 92 (79–106) | 103 (92–114) | <0.001 |
| Protein C | 23 (17–29) | 15 (10–20) | 51 (47–56) | 14 (9–18) | <0.001 |
| INTEM-CFT | 323 (154–492) | 332 (179–486) | 211 (115–306) | 235 (121–348) | 0.468 |
| INTEM-MCF | 67 (55–79) | 52 (41–63) | 64 (57–71) | 58 (52–64) | <0.001 |
| HEPTEM-CFT | 92 (35–149) | 89 (46–132) | 136 (85–187) | 105 (65–146) | 0.5416 |
| HEPTEM-MCF | 69 (65–74) | 67 (63–71) | 70 (65–74) | 60 (57–63) | 0.001 |
| EXTEM-CFT | 108 (87–130) | 144 (127–160) | 105 (90–121) | 179 (164–194) | <0.001 |
| EXTEM-MCF | 75 (71–78) | 71 (68–74) | 71 (68–74) | 63 (61–65) | <0.001 |
| FIBTEM-MCF | 29 (26–33) | 23 (20–26) | 23 (20–26) | 16 (14–19) | <0.001 |
Abbreviations: aPTT Activated partial thromboplastin time, AT Anti-thrombin, CFT Clot formation time, ECMO Extracorporeal membrane oxygenation, Fib(C) Clauss fibrinogen, FVIII Factor VIII, FXII Factor XII, Hb Haemoglobin, MCF Maximum clot firmness, PLT Platelets, PT Prothrombin time, RCC Red cell count, S-ALI Smoke-induced acute lung injury, TCT Thrombin clotting time, vWAg von Willebrand factor antigen, WCC White cell count
Data are presented as predicted mean (95% CI)