Table 2.
Interaction analyses of the HIF3A rs3826795 polymorphism and obesity on plasma ALT
| Mean ± SD of logALT (IU/L) | ||||||
|---|---|---|---|---|---|---|
| AA (n = 535) | AG (n = 985) | GG (n = 468) | β’ | P | P inter | |
| Total | 1.11 ± 0.27 | 1.12 ± 0.27 | 1.14 ± 0.28 | 0.020 | 0.340 | |
| Non-obese | 1.04 ± 0.25 | 1.06 ± 0.23 | 1.05 ± 0.23 | −0.009 | 0.741 | 0.042 |
| Obese | 1.24 ± 0.26 | 1.25 ± 0.30 | 1.30 ± 0.29 | 0.075 | 0.037 | |
β’ stands for the standardized coefficient of G allele number in the model
P inter stands for the P value of the interaction term in the linear regression model, including logALT as the dependent variable, and SNP, obesity group, SNP × obesity group, age, age2 and gender as independent variables
HIF3A: Hypoxia Inducible Factor 3 Alpha Subunit; ALT alanine aminotransferase