Figure 4.

Sensitivity analysis of model parameters. The mean relative nucleotide substitution rate at the population level in the immunocompromised population compared to the general population $〈K_c〉$ (from sampling 1000 points of the parameter space using Latin Hypercube Sampling) as a function of the proportion of immunocompromised hosts ($c$), for a range of values of the quarantine parameter ($q$), and the ratio of substitution rates (at the individual host level) ($k_c/k$). (a) SIRS model with $1/{\gamma }_c=1$ month and $N={10}^6$; (b) SIRS model with $1/{\gamma }_c=1$ year and $N={10}^6$. Blue lines with square markers indicate $k_c/k=10$, red lines with diamond markers $k_c/k=1$, and black lines with circle markers $k_c/k=0.1$. Dotted lines indicate $q=0.1$, dashed lines $q=0.5$ and solid lines $q=0.9$. Here $1/\gamma =7$ days and $1/{\theta }_c=3$ days.