Table 2.
Fasting Plasma Glucose | 2-hour Plasma Glucose | Gestational Diabetes | ||||
---|---|---|---|---|---|---|
β (95% CI) | P | β (95% CI) | P | OR (95% CI) | P | |
Folate | ||||||
Unadjusted | -0.03 (-0.06, 0.001) | 0.056 | 0.26 (0.16, 0.35) | 0.001 | 1.40 (1.17, 1.68) | 0.001 |
Model 1 | -0.02 (-0.06, 0.01) | 0.124 | 0.17 (0.08, 0.27) | 0.001 | 1.30 (1.07, 1.59) | 0.009 |
Model 2a | -0.02 (-0.05, 0.02) | 0.358 | 0.15 (0.04, 0.25) | 0.014 | 1.29 (1.01, 1.60) | 0.039 |
Vitamin B12 | ||||||
Unadjusted | -0.06 (-0.09, -0.03) | 0.007 | -0.09 (-0.19, 0.001) | 0.050 | 0.83 (0.70, 0.98) | 0.028 |
Model 1 | -0.04 (-0.07, -0.01) | 0.008 | -0.06 (-0.15, 0.03) | 0.224 | 0.86 (0.72, 1.03) | 0.094 |
Model 2b | -0.04 (-0.07, -0.01) | 0.016 | -0.09 (-0.18, -0.003) | 0.044 | 0.81 (0.68, 0.97) | 0.024 |
Vitamin B6 | ||||||
Unadjusted | -0.02 (-0.05, 0.01) | 0.284 | 0.17 (0.08, 0.26) | 0.001 | 1.20 (1.01, 1.43) | 0.039 |
Model 1 | -0.02 (-0.05, 0.01) | 0.159 | 0.13 (0.04, 0.22) | 0.003 | 1.20 (0.996, 1.44) | 0.055 |
Model 2c | -0.005 (-0.04, 0.03) | 0.747 | 0.10 (-0.0005, 0.19) | 0.051 | 1.14 (0.94, 1.39) | 0.175 |
Homocysteine | ||||||
Unadjusted | -0.03 (-0.06, 0.005) | 0.106 | -0.17 (-0.27, -0.08) | 0.001 | 0.75 (0.63, 0.90) | 0.002 |
Model 1 | -0.03 (-0.06, -0.0002) | 0.048 | -0.15 (-0.24, -0.06) | 0.001 | 0.75 (0.62, 0.91) | 0.003 |
Model 2d | -0.05 (-0.08, -0.02) | 0.002 | -0.12 (-0.21, -0.02) | 0.012 | 0.76 (0.62, 0.92) | 0.006 |
Effect estimates are per 1-SD increment in log-transformed concentrations of plasma folate, vitamins B6 and B12, and homocysteine.
Model 1 adjusted for maternal age, ethnicity, education, income, smoking, alcohol intake, physical activity, pre-pregnancy BMI, parity, family history of diabetes, and previous occurrence of GDM.
Model 2 adjusted as for Model 1 and aplasma B6 and B12; bplasma folate and B6; cplasma folate and B12; dplasma folate, B6, and B12