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. Author manuscript; available in PMC: 2017 Nov 1.
Published in final edited form as: Clin Pharmacol Ther. 2016 Sep 23;100(5):537–547. doi: 10.1002/cpt.428

Figure 4.

Figure 4

Effect of SNP combinations in CSMD1, SLC22A2, and WWOX on the dynamics of HbA1c levels. A: Simulated median HbA1c levels (with 95% CI bands) over 5 years comparing carriers and non-carriers of CSMD1 minor (risk) alleles. B: Simulated median HbA1c levels over 5 years comparing carriers and non-carriers of SLC22A1/WWOX genes minor alleles. Blue shaded region with solid line: Simulated median for patients carrying no minor alleles with 5th and 95th confidence interval. Red/green shade with dashed line: Simulated median for patients carrying minor alleles of labeled gene(s) with 5th and 95th confidence interval of median.