Table 2.
Comparison of laboratory data of children with HbSC with TAMMV velocities defined using a cutoff value of 125.75 cm/s (75th percentile).
| Laboratory value | TAMMV < 125.75 cm/s | TAMMV ≥ 125.75 cm/s | p value∗ | ||
|---|---|---|---|---|---|
| N | Mean ± SD | N | Mean ± SD | ||
| Hemolysis markers | |||||
| RBC, ×1012/L | 46 | 4.44 ± 0.48 | 16 | 4.18 ± 0.49 | 0.073 |
| Hemoglobin, g/dL | 46 | 11.58 ± 0.81 | 16 | 11.04 ± 1.12 | 0.042 |
| Hematocrit, % | 46 | 33.40 ± 2.45 | 16 | 31.68 ± 3.59 | 0.037 |
| MCV, fL | 46 | 75.63 ± 5.63 | 16 | 75.87 ± 3.77 | 0.877 |
| MCH, ρg | 46 | 26.30 ± 2.53 | 16 | 26.48 ± 1.58 | 0.783 |
| MCHC, g/dL | 46 | 34.90 ± 0.76 | 16 | 34.95 ± 0.79 | 0.532 |
| RDW, % | 46 | 16.00 ± 1.34 | 16 | 15.19 ± 0.90 | 0.010 |
| Reticulocyte count, % | 45 | 4.05 ± 1.94 | 16 | 3.74 ± 1.62 | 0.787† |
| Total bilirubin, mg/dL | 51 | 1.27 ± 1.15 | 17 | 1.08 ± 0.89 | 0.237† |
| Direct bilirubin, mg/dL | 51 | 0.30 ± 0.13 | 17 | 0.27 ± 0.14 | 0.288† |
| Indirect bilirubin, mg/dL | 51 | 0.97 ± 1.08 | 17 | 0.80 ± 0.77 | 0.357† |
| LDH, U/L | 50 | 584.92 ± 201.47 | 15 | 531.67 ± 110.50 | 0.528† |
| NOx, μM | 50 | 31.56 ± 6.36 | 16 | 27.75 ± 4.20 | 0.029 |
| Iron metabolism | |||||
| Serum iron, mcg/dL | 49 | 69.30 ± 22.89 | 16 | 77.88 ± 22.91 | 0.180† |
| Ferritin, ηg/mL | 47 | 102.82 ± 62.63 | 17 | 177.50 ± 202.97 | 0.029 † |
RBC: red blood cells; MCV: mean cell volume; MCH: mean cell hemoglobin; MCHC: mean corpuscular hemoglobin concentration; RDW: red cell distribution width; LDH: lactate dehydrogenase; NOx: nitric oxide metabolites; SD: standard deviation; significant p values are shown in bold. ∗p value using t-test; †p value using Mann–Whitney.