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Podocyte EMT. In elevated glucose levels, the TGF-β1/Smad signal pathway resulted in increased protein expression of Snail in cultured podocytes, which induced podocyte EMT. Additionally, AngII promoted translocation of β-catenin/LEF-1 complexes into the nucleus through the enhancement of ILK in transitioning epithelia, where they downregulated CD2AP expression via promoting EMT transcription in podocytes.
