TABLE V.
Anthropometrics and orthopedics for individuals with Angelman syndrome, late-adolescence through adulthood
| Full Cohort % (n) |
Female odds ratio |
21–25y odds ratio |
26–30y odds ratio |
31–50y odds ratio |
UBE3A odds ratio |
UPD odds ratio |
|
|---|---|---|---|---|---|---|---|
|
|
|||||||
| Anthropometrics | |||||||
| Height (m) | 1.62 (0.114, 109) | −0.135** | −0.003 | 0.025 | −0.012 | −0.010 | 0.030 |
| Body Mass Index | 23.72 (4.679, 109) | 1.085 | 0.423 | 0.931 | 1.525 | 1.582 | −0.210 |
| Underweight | 9% (109) | 1.655 | 0.352 | 0.220 | IS (0%, 16) | 0.903 | IS (0%, 10) |
| Overweight | 22% (109) | 0.415 | 0.637 | 0.349 | 0.553 | 0.889 | 0.346 |
| Obese | 10% (109) | 12.468* | 1.418 | 2.048 | 1.853 | 2.735 | 1.063 |
| Orthopedics | |||||||
| Hypertonia | |||||||
| Knee contracture | 43% (109) | 1.107 | 1.266 | 1.005 | 2.007 | 2.933 | 3.422 |
| Tendon lengthening surgery a | 20% (85) | 0.299* | 0.503 | 0.151 | 1.178 | 1.778 | 0.762 |
| Scoliosis | 50 (109) | 1.491 | 1.985 | 0.559 | 1.045 | 0.680 | 0.437 |
| Age at scoliosis diagnosis δ | 12.06 (sd: 5.603, n=49) | 0.258 | 1.968 | 2.759 | 3.629 | −3.974 | 1.259 |
| Scoliosis, mild | 61% (54) | 2.521 | 0.793 | 1.239 | 1.239 | IS (0%, 4) | IS (100%, 5) |
| Scoliosis, severe | 39% (54) | 0.397 | 1.261 | 0.807 | 0.807 | IS (0%, 4) | IS (0%, 5) |
| Surgical intervention | 24% (54) | 0.207* | 1.000 | 0.613 | 0.250 | IS (0%, 4) | IS (0%, 5) |
| Bone density | |||||||
| Osteoporosis/osteopenia | 16% (109) | 1.137 | 5.684* | 1.208 | 2.920 | IS (0%, 9) | 1.071 |
| History of broken hip or femur | 7% (109) | 1.776 | 1.423 | 1.873 | 2.783 | 1.417 | 1.259 |
Age sub-groups compared with the 16–20y cohort. Genotype sub-groups compared with the Del cohort.
a
hamstring and/or achilles. δ. regression coefficient listed for each covariate.
*
statistically significant odds ratio (α = 0.05).
**
statistically significant regression coefficient (α=0.05). IS: infinite solution (%, n), m: meters.